Rora | RAR-related orphan receptor alpha
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Roratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.05x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Roratm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.07x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Roratm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Rora mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rora.
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| Roratm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Roratm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Roratm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |